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Title : Post Doctoral Fellow
Reports to : Scientist II, Oncology Biology
Department : Discovery (Oncology)
Grade : two-year fixed-term contract
Location: UK, Cambridge
* Establish intravital optical imaging model for investigating immune cell function in the tumour microenvironment.
* Validate immune cell characteristics within the tumour microenvironment
* Develop relevant endpoints to support longitudinal studies
* Develop, design and run in vivo tumour model experiments (e.g. flank, orthotopic) to achieve project milestones.
* Communicate results, conclusions and recommendations to colleagues, line manager and multi-disciplinary teams.
* Acquire and maintain relevant technical and intellectual expertise in imaging, immunology and tumour biology.
* Be a highly organised, self-motivated individual with a strong practical background.
Essential: Must have a range of pharmacological skills that can be applied to evaluation of therapeutic antibodies for cancer. These may include:
1. Expertise in optical/confocal imaging
2. In vivo tumour models (subcutaneous, orthotopic and genetically engineered mouse models)
3. Tissue culture expertise
4. Knowledge of Home Office Regulations or equivalent
5. Animal dissection and tissue collection
6. Endpoint analysis, e.g. FACS, IHC, ELISA
7. Data processing, analysis and interpretation
8. Statistical analysis
Desirable: The in vivo oncology Biology team is keen to expand its expertise and would value experience in the following areas:
1. Tumour immunology experience
2. Vascular modulation experience
Essential: First degree, HND/HNC or equivalent qualification in biological sciences.
Desirable: PhD in biochemistry, cell biology, immunology, pharmacology or relevant subject with strong preclinical knowledge. Home Office Licence (Modules 1-3)
Essential: Candidates should have practical imaging experience as well as experience running in vivo tumour models and using pharmacodynamic endpoints.
Desirable: Tumour immunology expertise. Knowledge of drug discovery process particularly in a pharmaceutical environment.
* Transfer intravital confocal microscopy endpoints to tumour microenvironment.
* Develop and validate in vivo models to support project progression.
* Design, implement, analyse, interpret and record studies (e.g. tumour growth delay or immune response models) to understand the effect of drugs in complex model systems.
* Test candidate antibodies for activity and characterise their properties through the use of in vivo models.
* Acquire a thorough knowledge of specific equipment relating to imaging and in vivo models.
Team Responsibilities and Communication
* Work in a flexible, collaborative style in support of colleagues within and outside team, and across geographical locations.
* Co-ordinate studies between animal technicians and cell culture staff on a day-to-day basis.
* Maintain an awareness of scientific and technical literature and use this knowledge to progress projects and communicate new ideas to the in vivo team.
* Analyse results and compile data summaries for project meetings and reports.
* Contribute to the writing of study reports.
* Develop and maintain intellectual knowledge in the tumour immunology and tumour microenvironment biology field as relevant to MedImmune projects
* Acquire and develop practical expertise in tumour immunology (in vivo models and ex vivo assays).
* Contribute to project progression, capability development, written reports and publications.
* Maintain awareness of developments in the field of cancer cell biology and immunology.
Health and Safety
* Work to Home Office Regulations.
* Be aware of and observe company policies on Health and Safety.
* Comply with relevant practices set out in the Code of Practice for working with Genetically Modified Organisms.
* Share the responsibility for ensuring that colleagues comply with MedImmune Ltd standards.
Furthermore applicants must fulfil the following eligibility criteria:
1. Be in possession of a doctoral degree, independently of the time taken to acquire it or having at least 4 years of research experience (full-time equivalent) after obtaining the degree which formally allows them to embark on a doctorate in the country in which the degree/diploma was obtained or in the country where the initial training activities are provided.
2. The research experience of an experienced researcher recruited for initial training may not exceed 5 years post first degree at the time of the appointment.
3. The candidate may have not been resident in the United Kingdom for more than 12 months in the last three years.