Research Scientist or Research Associate - Translational Research - London

5 days left

Competitive salary and benefits package
Aug 24, 2016
Oct 06, 2016
Result Type
Position Type
Full Time

Research Scientist or Research Associate - Translational Research

Grade: Research Scientist or Research Associate
Reports to: Senior Scientist – Translational Research
Department: Translational Research
Hours: Full time
Salary range: Competitive salary and benefits package, including a pension scheme, life assurance, group income protection and private medical insurance
Location: London, W12

About Autolus

Autolus is a private biopharmaceutical company, focused on the development and commercialisation of engineered T-cell immunotherapy products based on its proprietary T-cell programming technology. The company has a differentiated product pipeline coupled with a strong technology platform to ensure long-term sustainability. Autolus has strong financial backing and the ambition to become a global leader in T-cell therapy for treatment of cancer patients.

Founded on the work of Dr Martin Pule, an academic clinical haematologist and thought-leader in T-cell engineering, the Autolus team is developing CAR T-cell products that can specifically and safely destroy malignant cells and provide long-term protection from recurrence of the tumour. We are currently scaling up our in-house capabilities in research, pre-clinical development, manufacturing and clinical development. We are building a leading biotechnology company with the ambition to be a leader of a revolution in medicine in which life-threatening diseases are treated by a patient’s own cells. This is a fantastic opportunity to join a fast-moving, innovative company that’s going places, and to make a real impact from early on.

Autolus was founded in 2014 by Syncona Partners LLP and UCL Business PLC, the wholly-owned technology transfer company of University College London.  Established in 2012, Syncona is a subsidiary of the Wellcome Trust.

Role Summary

We are seeking an enthusiastic, pro-active individual to work at either a Research Associate or Research Scientist (depending on level of experience and qualifications) in our state-of-the-art laboratories in West London.  You will be motivated and highly organised with knowledge of immunology/haematology and have experience in clinical or research-based assays, particularly flow cytometry and PCR, as well as an ability to work to a high standard.  The candidate will work in a small team to support the development of biomarker assay validation plans and QC procedures. Responsibilities include the hands-on analysis of clinical samples from multiple phase I/II clinical trials and subsequent data analysis and presentation. You will also have the opportunity to support pre-clinical research projects within the company aiming to develop state of the art CAR T cell products.

Key Responsibilities

  • Assist in the development of validation plans, SOPs and QC procedures for clinical assays
  • Hands-on analysis of clinical samples by flow cytometry, qPCR and multiplex cytokine analysis
  • Follow appropriate regulatory standards for the receipt, processing and storage of clinical samples and reporting of data
  • Assist in developing robust clinical assays to characterise CAR T-cell products
  • Maintain accurate and clearly written laboratory notebooks to standard required for legal requirements, regulatory filings, publications and patent filings
  • Train others in the use of the technology as appropriate
  • Any other duties as required following consultation with the post holder
  • The post-holder will be responsible for adhering to all health and safety guidance, provided by the Company

Demonstrated skills and competencies

E – Essential
P - Preferred


  • Experience in Pharma and/or Biotech in Immunology or Haematology or as a Biomedical Scientist/MLSO (E)
  • Skilled in at least one of the following (with full training given if required): flow cytometry, PCR and multiplex cytokine analysis although full training will be given if required (P)
  • Experience in working in a regulated environment e.g. to GCLP (P)
  • Experience of validating cell-based assays to ICH standards (P)


  • An BSc/MSc with appropriate experience - Research Associate level (E).
  • An PhD with appropriate experience - Research Scientist level (E)

Skills/Specialist knowledge

  • Excellent organisational skills with the ability to present results clearly and logically, working co-operatively as part of a team as well as independently (E)
  • Good attention to detail and ability to accurately follow SOPs (E)
  • Ability to identify and implement solutions (E)
  • Commitment to high quality work (E)

To apply, please click on the 'Apply' button.

We expect to have a high number of applicants for this post and we would advise that you apply quickly as we may close the advert early.