Research Scientist or Research Associate - Translational Research - London

5 days left

Location
London
Salary
Competitive salary and benefits package
Posted
Aug 24, 2016
Closes
Oct 06, 2016
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

Research Scientist or Research Associate - Translational Research

Grade: Research Scientist or Research Associate
Reports to: Senior Scientist – Translational Research
Department: Translational Research
Hours: Full time
Salary range: Competitive salary and benefits package, including a pension scheme, life assurance, group income protection and private medical insurance
Location: London, W12


About Autolus

Autolus is a private biopharmaceutical company, focused on the development and commercialisation of engineered T-cell immunotherapy products based on its proprietary T-cell programming technology. The company has a differentiated product pipeline coupled with a strong technology platform to ensure long-term sustainability. Autolus has strong financial backing and the ambition to become a global leader in T-cell therapy for treatment of cancer patients.

Founded on the work of Dr Martin Pule, an academic clinical haematologist and thought-leader in T-cell engineering, the Autolus team is developing CAR T-cell products that can specifically and safely destroy malignant cells and provide long-term protection from recurrence of the tumour. We are currently scaling up our in-house capabilities in research, pre-clinical development, manufacturing and clinical development. We are building a leading biotechnology company with the ambition to be a leader of a revolution in medicine in which life-threatening diseases are treated by a patient’s own cells. This is a fantastic opportunity to join a fast-moving, innovative company that’s going places, and to make a real impact from early on.

Autolus was founded in 2014 by Syncona Partners LLP and UCL Business PLC, the wholly-owned technology transfer company of University College London.  Established in 2012, Syncona is a subsidiary of the Wellcome Trust.


Role Summary

We are seeking an enthusiastic, pro-active individual to work at either a Research Associate or Research Scientist (depending on level of experience and qualifications) in our state-of-the-art laboratories in West London.  You will be motivated and highly organised with knowledge of immunology/haematology and have experience in clinical or research-based assays, particularly flow cytometry and PCR, as well as an ability to work to a high standard.  The candidate will work in a small team to support the development of biomarker assay validation plans and QC procedures. Responsibilities include the hands-on analysis of clinical samples from multiple phase I/II clinical trials and subsequent data analysis and presentation. You will also have the opportunity to support pre-clinical research projects within the company aiming to develop state of the art CAR T cell products.


Key Responsibilities

  • Assist in the development of validation plans, SOPs and QC procedures for clinical assays
  • Hands-on analysis of clinical samples by flow cytometry, qPCR and multiplex cytokine analysis
  • Follow appropriate regulatory standards for the receipt, processing and storage of clinical samples and reporting of data
  • Assist in developing robust clinical assays to characterise CAR T-cell products
  • Maintain accurate and clearly written laboratory notebooks to standard required for legal requirements, regulatory filings, publications and patent filings
  • Train others in the use of the technology as appropriate
  • Any other duties as required following consultation with the post holder
  • The post-holder will be responsible for adhering to all health and safety guidance, provided by the Company


Demonstrated skills and competencies

E – Essential
P - Preferred

Experience

  • Experience in Pharma and/or Biotech in Immunology or Haematology or as a Biomedical Scientist/MLSO (E)
  • Skilled in at least one of the following (with full training given if required): flow cytometry, PCR and multiplex cytokine analysis although full training will be given if required (P)
  • Experience in working in a regulated environment e.g. to GCLP (P)
  • Experience of validating cell-based assays to ICH standards (P)

Qualifications

  • An BSc/MSc with appropriate experience - Research Associate level (E).
  • An PhD with appropriate experience - Research Scientist level (E)

Skills/Specialist knowledge

  • Excellent organisational skills with the ability to present results clearly and logically, working co-operatively as part of a team as well as independently (E)
  • Good attention to detail and ability to accurately follow SOPs (E)
  • Ability to identify and implement solutions (E)
  • Commitment to high quality work (E)

To apply, please click on the 'Apply' button.

We expect to have a high number of applicants for this post and we would advise that you apply quickly as we may close the advert early.