Analytical Development Scientist (AS I/II) - Influenza Manufacturing Science & Technology

Employer
Location
UK, Liverpool
Posted
Sep 01, 2016
Closes
Sep 29, 2016
Ref
5000133787210
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

The Influenza Manufacturing Science and Technology group is a multi-disciplinary scientific function providing expertise in Virology, Process Development and Analytical Development responsible for influenza strain development for manufacture of the seasonal live attenuated influenza vaccine. The Analytical Development Group, is a dynamic function with a strong focus on science and technology, accountable for analytical development providing expertise in analytical biochemistry, microbiology, immunology, cell culture, validation, laboratory automation, validation, and technology transfer. Core capabilities are tightly aligned with our pipeline, business strategy and enable important medicines to be manufactured, tested and delivered to patients.

The job holder will play an important role in the Analytical Development function by supporting analytical characterisation and testing of Influenza strains, during strain development activities enhancing the scientific understanding of Influenza.

We are seeking a talented scientist in a laboratory-based cell based role. Specifically the role will be within the Analytical Development team, developing, optimising and performing in vitro cell based assays and binding assays, with a focus on maintenance of cells, cell banking, culture expansion and implementation of robotic automation systems within a cell culture environment.

Role Responsibilities

  • Aseptic techniques and cell culture requirements for primary, clonal and recombinant cell lines
  • Optimisation and automation of cell culture, and implementation of analytical technologies, such as real time cell monitoring and automated cell counting
  • Cell banking and characterisation
  • Development and optimisation of novel potency assays within the team, with a specific requirement for hands-on in vitro cell-based assay and binding assay expertise
  • Day-to-day problem solving, work prioritisation, and co-ordination across the team and other groups to ensure study and project requirements are met to timelines.
  • Independently interpret data and make recommendations from findings.
  • Involvement in and managing of scheduling, operational and maintenance duties required within the laboratory.
Maintain awareness of new technologies, current industrial technical and scientific literature. Selection and development of new techniques within the team to further develop in-house technology.

Your previous experience will demonstrate knowledge and practical experience of:

  • Analytical development, method validation and technology transfer of a range of Virology/Immunological, Biosafety/Tissue culture and Analytical Chemistry methods, with experience in technology transfer, method and operational improvements
  • Ability to aseptic culture and maintain cell lines (primary, clonal, transfected)
  • Improvement in cell culture technologies, through robotics and analysis systems
  • Development and optimisation of cell-based potency assays
  • Virology and infectivity assays, eg TCID50, FFA, plaque assays
  • Analytical techniques, ELISA, SDS-PAGE, Western Blotting, PCR methods

Ideally you will also demonstrate/knowledge of:

  • Ability to handle multiple projects simultaneously and effectively contribute to project teams.
  • Excellent communication, organisation, attention to detail and team skills.
  • High level of initiative, independence and the ability to execute lab work under minimal supervision, in a fast-paced environment

Education/Experience

  • To have a science degree or equivalent in Biochemistry, Microbiology, Molecular Biology, Virology or other science related field, as a minimum

Competitive remuneration and company benefits apply.

Closing date for applications -- August 29 th 2016

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation