Research Scientist (ASII) ,Oncology - 1 year Fixed Term Contract, Cambridge UK
3 days left
- Full Time
MedImmune is seeking to recruit a talented Research Scientist for a lab-based position in the oncology team. The successful applicant will be responsible for supporting and helping to drive a new project to design and test novel biologics that promote anti-tumour immunity. The project will be highly relevant to specific areas of unmet medical need within oncology and will target cells of the tumour microenvironment such as myeloid cells, stromal fibroblasts or T-cells.
- Laboratory based position conducting i n vitro immune cell assays to support immunotherapy projects with a particular focus on tumour myeloid biology.
- Develop, design, run and analyse in vitro human immunology experiments relevant for cancer immunotherapy.
- Acquire and maintain a strong expertise in techniques for immunological phenotyping (e.g. flow cytometry) and effector function (e.g. proliferation, cytokine/chemokine release [e.g. MSD, ELISA], target cell killing assays).
- Stay up to date with relevant technical and intellectual scientific expertise in tumour immunology.
- Oral and written communication of results, conclusions and recommendations to colleagues, line manager and multi-disciplinary teams.
- Be a highly organised, self-motivated individual with a strong lab/practical background.
- Coach and supervise other team members in techniques as appropriate.
Perform in vitro assays using primary human immune cells to develop an understanding of the function of immunotherapies targeting tumour myeloid cells.
- Design, implement, analyse, interpret and record immune based assays (e.g. flow cytometry, MSD, ELISA) using human cells to understand the mechanism of action of cancer immunotherapeutics.
Team Responsibilities and Communication
- Work in a flexible, collaborative style in support of colleagues within and outside team, and across geographical locations (e.g. Cambridge, UK and Gaithersburg, US).
- Co-ordinate studies between different functions (e.g. cell culture staff on a day-to-day basis).
- Maintain an awareness of scientific and technical literature and use this knowledge to progress projects and be willing to communicate new ideas to the department.
- Analyse results and compile data summaries for project meetings.
- Contribute to the writing of study reports (e.g. lab books and presentations).
- Develop and maintain intellectual knowledge in tumour immunology.
- Acquire and develop practical expertise in tumour immunology.
- Contribute to capability development, written reports and publications.
- Candidates should have immunology or tumour biology expertise including in vitro primary human assay expertise, as evidenced by peer reviewed publications.
- Understanding and enthusiasm for tumour immunology and cancer therapies.
- Must have a range of in vitro skills that can be applied to cancer immunology research including:
- Tissue culture techniques for cell-based immunoassays.
- Experience working with human immune cells.
- Complex flow cytometry (including intracellular cytokine or multicolour cell surface staining); MSD; and ELISA.
- Data processing, statistical analysis and interpretation.
- Preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).
- Experience within the pharmaceutical or biotechnology industry, preferably within immuno-oncology.
- Publications in top tier scientific journals.
- The Cambridge Oncology Research team is keen to expand its expertise and would value experience in the following areas:
- Complex immunological assays (e.g. primary immune cell co-culture assays).
- Assays using immune cells derived from cancer patient tumour and blood.
Education and skills:
Essential: BSc or MSc in a relevant biological scientific discipline with a focus on immunology or
Desirable: PhD in oncology, cell biology, immunology, pharmacology or relevant subject with strong
Competitive remuneration and company benefits apply.
Closing date for applications - September 29th 2016
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation