Hybridoma Scientist (Scientist I/II)

5 days left

Employer
Location
UK, Cambridge
Posted
Sep 02, 2016
Closes
Sep 30, 2016
Ref
5000132162010
Discipline
Clinical, Quality
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

Based in Cambridge, the Antibody Discovery and Protein Engineering team are looking to employ a scientist to generate therapeutic antibodies and tool reagents using hybridoma technology and phage display.

 Some of the responsibilities include:

  •  Independently plan, design and conduct experiments to:
    • Isolate monoclonal antibodies by hybridoma technology including: design of appropriate immunization strategies, B-cell fusions, hybridoma selections, sequence analysis of hybridoma clones, hybridoma propagation and antibody purification.
    • Isolate antibodies from naïve antibody libraries using in vitro display technologies.
    • Generate tailored libraries and select for optimized variants using in vitro display technologies or rational engineering.
    • Characterise lead antibodies in biochemical and cell based assays.
  • Delivery of high quality work to a scientifically rigorous standard.
  • Provision of expert knowledge to multidisciplinary project teams to impact project-related decisions.
  • Co-ordination of project related activities to ensure all occur in a smooth and timely manner.
  • Definition and implementation of process improvements.
  • Assessment and implementation of technology improvements.
  • Effectively presenting results at internal meetings and external scientific meetings.
  • Contributing to MedImmune's external presence by publication in peer reviewed journals in the field.


To be considered, successful applicants will need to have the following background:

Education:

  • PhD or equivalent experience in a relevant discipline

Experience

Essential :

  • Proven practical scientific experience of isolating antibodies using hybridoma technology and/or phage display.
  • Knowledge of automation, informatics and data management
  • Ability to work in multi-disciplinary teams

Knowledge/skills

Essential :

  • Displays a general knowledge of drug development.
  • Experienced molecular biologist.
  • Excellent scientific communication skills enabling effective working with colleagues at all levels.
  • Ability to author and publications and raise external visibility of the team via conference presentations and other means.

Desirable:

  • Experience of biochemical and cell based screening.

Closing date for applications is October 1st 2016.

Competitive remuneration and company benefit will apply

*LI-MEDI

*NS-Medi

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation