Principal Scientist, Exploratory Toxicology

3 days left

San Diego, CA US
Competitive Salary
Sep 03, 2016
Oct 01, 2016
Chemistry, Toxicology
Result Type
Position Type
Full Time


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The Principal Scientist in Exploratory Toxicology serves as an integral member of the toxicology team that supports the early stage discovery and development of pharmaceuticals, including the identification, mechanistic investigation, and management of safety risk from initial Target Identification to Development Candidate nomination stages. In general, scientist will provide appropriate scientific perspective to identify safety issues of a potential drug candidate early in the drug development process. This scientist will manage and supervise scientific, administrative, and technical activities related to In Vitro Toxicology.  Additionally, this individual will provide expertise in genotoxicity screening assays and help support mechanistic studies of later stage development compounds.


The Principal Scientist is also responsible for assisting the San Diego Nonclinical Development management team in establishing and achieving long-term strategic goals and tactical objectives.

Responsibilities will also include, but are not limited to, the following:

1. Design and conduct in vitro and molecular toxicology experiments focused on identification of mechanistic basis of toxicity including the following capacities.

a.   Characterization of gene expression changes using PCR and/or available gene chip technology.

b.   Proteomics using Western blot and immuno-based imaging techniques

c.   Tissue culture systems such as conventional cell culture, co-culture models, organ culture systems, and utilization of stem cells

d.   Evaluation of data using appropriate software, and  interpretation/integration of results from multiple molecular endpoints to generate reports with a focus on toxicological relevance

e.   Work collaboratively to integrate data from molecular endpoints with traditional toxicity endpoints

2. Serve as Discovery Project Team toxicology representative and manage safety risk identification program for that project(s).

3. Contribute to identification of early target safety risk based on projected mechanism of pharmaceutical action, literature knowledge on pathways and/or toxicological profile of competitor drugs (conduct target safety assessments for novel drug targets).

4. Maintain in vitro and molecular toxicology expertise through organizational associations, literature review, continuing education, and publications.

5. Establish and maintain working relationship with key opinion leaders in the toxicology community, academicians, and key Celgene staff

6. Support Exploratory Toxicology by

a.   Evaluating and implementing novel in vitro toxicology models and assays

b.   Conducting and managing in vitro toxicology screening assays, including genotoxicity testing

c.   Supervise and mentor scientific staff

d.   Publishing findings

e.   Addressing potential development issues and conducting risk mitigation activities

f.    Address scientific issues using knowledge of molecular t oxicology





Requires PhD degree in toxicology or related fields and 8 years of drug development experience within the pharmaceutical industry, with a focus on cellular and molecular toxicology.  Requires a thorough understanding of early stage drug discovery and development process.  American Board of Toxicology certification desired, but not required.  Expertise in automation also desired. 

Skills/Knowledge Required:

  • Advanced knowledge of general, cellular, and molecular toxicology principles. 
  • Experience conducting mechanistic investigative studies involving signal transduction pathways, proteomics, and genomics.
  • Demonstrable knowledge and skills in toxicology drug development.
  • Strong written and verbal communication skills and computer proficiency are required.
  • Working collaboratively with colleagues in other Departments and Project Teams.
Ability to multi-task and work in a collaborative team environment.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.