Senior Scientist, Analytical Development, Biologics

2 days left

Employer
Location
San Diego, CA US
Salary
Competitive Salary
Posted
Sep 05, 2016
Closes
Oct 03, 2016
Ref
16001616
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture

 

The successful candidate will be a highly motivated individual ready to work within a science-focused, collaborative, and multidisciplinary drug development environment.  The position will lead the bioanalytical duties within the San Diego Biologics Formulation Development group and will focus on analytical characterization of therapeutic proteins including antibodies, bispecific antibodies and antibody-drug conjugates (ADCs). Responsibilities will include supporting formulation development and molecular/developability assessment activities and presenting results on a regular basis.  The position is laboratory-based and located at Celgene’s Discovery Site in San Diego, CA. 

 

Responsibilities will include, but are not limited to, the following:


Design and implement experiments for the characterization of therapeutic antibodies and ADCs.

Design and lead successful execution of experiments for comparability and developability assessments.

Support formulation of therapeutic antibodies and ADC drug substances and drug products.

Advance product understanding and promote innovative approaches to support early-stage discovery and drug development activities.  

Work in close collaboration with formulation and Biotherapeutics discovery scientists

Collaborate with project teams, outside partners, contract research/manufacturing organizations and other functions within Discovery andDevelopment  

Be a hands-on presence in the laboratory.

Manage a group of scientists and associates.  Recruit and hire additional analytical professionals as portfolio demands dictate. Provide technical guidance,  supervise and develop scientific staff. 

Specify, purchase, install and maintain analytical equipment for the Biologics formulation laboratory.

Serve on and lead departmental, interdepartmental and project teams as required.

Write formal reports, methods and procedures.

Train personnel on use of equipment and methods.

Adhere to all relevant compliance requirements.


*LI-KM1


Qualifications
Ph.D. in Analytical Chemistry, Biochemistry or relevant discipline and 6 years biotech/pharmaceutical laboratory experience.  M.S. or B.S. in the same fields with 8 and 10+ years experience, respectively.

Skills/Knowledge Required:
Comprehensive knowledge of therapeutic protein/antibody and ADC analytics and characterization. Demonstrated experience in bioanalytical characterization, and stability testing of therapeutic proteins, antibodies and ADCs in the early stages of product development. In-depth knowledge of protein biologics critical quality attributes and post-translational modifications In-depth knowledge of analytical method development for  HPLC (RP, SEC, IEC, NP, and HIC), capillary electrophoresis (CE), capillary isoelectric focusing (cIEF), SDS-PAGE, and glycan analysis. Extensive experience and understanding of mass spectrometric techniques particularly with developing and implementing LC-MS methods using TOF and Orbi-trap instruments for intact mass analysis, reduced and non-reduced peptide map analysis.  (experience with Thermo LTQ  series preferred) Strong problem-solving and troubleshooting, experimental design and data interpretation skills. Ability to provide scientific guidance, leadership and training to others within/outside the department.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.


Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.