Sr. Scientist, Immunology, Oncology & Cell Biology

6 days left

Warren, NJ US
Competitive Salary
Sep 06, 2016
Oct 04, 2016
Clinical, Research
Result Type
Position Type
Full Time


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


General Responsibilities:

The Research & Development Group at Celgene Cellular Therapeutics is seeking a highly motivated Senior Scientist to join a group of researchers evaluating novel cell therapies in the field of cancer immunotherapy. The candiate will have 5-10 yrs of academic or pharmaceutical industry experience in the design and implementation of immune-based assays, cell-based assays, molecular biology studies and pertinent experimental models. A strong background in cellular and molecular immunology, immune system development, stem cell biology, and primary cell culture is required. The candidate will be responsible for performing the laboratory based studies to generate the nonclinical PoC datasets, enable IND submissions and conduct the translational studies to support product clinical development. The candidate is expected to support internal and external collaborative projects, provide experimental design expertise, conduct data analysis of in vitro and in vivo studies, and provide regular research progress report, both written and oral, and manuscript generation.


Responsibilities include, but are not limited to, the following:

• Work within a matrix team to develop novel therapeutic approaches for a cell-based immune product in various therapeutic indications

• Make direct impact on the performance of multiple departments. Impact is achieved by driving team e?orts and leading projects

• Provides input and makes recommendations to research strategies

• Provides scientific leadership and accountability to accelerate development and to provide insight into cellular product mechanisms and disease biology

• Independently design and implement long-term project plans, and interpret experiments to define efficacy, combination strategies and mechanism of action of the cellular product via gene, protein and function-based in vitro assessments

• Improve current functional assessment approaches by designing pertinent novel cell-based assays and/or cellular immune-based assays

• Participates in management of external collaboration and CROs. Provide recommendations for, and implement studies and strategies to define the potential of the cellular product in pertinent in vivo studies

• Identify and engage external experts and key opinion leaders to facilitate external assessment or collaborative opportunities to evaluate the cellular product

• Represents the Research & Development Group in Project team/Franchise team, other cross-functional teams as needed

• Provide scientific progress reports to the Senior Director and/or Senior Management as required

• Prepare IND format documentation and / or reports based on scientific results as required

• Creates disease specific translational goals, and author the translational section of the clinical protocols in trials

• Creates SOW and interfaces with CRO for execution of services

• Leads the analysis of translational correlative studies for the clinical studies by working with relevant functions and CRO as needed and generates the study reports

• Provide scientific leadership to the research team, as well as, create and track achievable goals for the team that are aligned with Corporate and Divisional Objectives.






• The successful candidate should have a PhD or MD/PhD degree in Immune Cell Biology (such as NK Cell, T Cell), Immunology, Translational Science, Oncology, or related field

• The position requires a minimum of 5 years of hands-on relevant experience with a track record of success as evidenced by a strong publication record, and/or, evidence of sustained contributions in the biopharmaceutical industry

• Advanced multi-parameter flow cytometry skills are required

• The candidate must have demonstrated expertise of a wide range of in vitro cellular and biochemical assays, including cell isolation and culture, molecular biology, cellular immunology assays and familiarity with in vivo models of immune disease or oncology are required. Broad knowledge of current scientific areas and technologies

• Basic understanding of MDS/AML, Lymphoma, Multiple Myeloma, CLL or related hematological malignancies and/or solid tumors

• Functional area expert with skills, independent critical thinking, theoretical knowledge and experience to apply scientific direction and approach to projects and problems

• Qualified candidate should be adept at independently designing, executing and interpreting immunology based experimentsThe individual is also expected to establish and manage productive collaborations with academic researchers and contribute to the scientific community by publishing results in high quality journals

• Proven scientific/leadership expertise, such as working functionally matrixed teams and to mentor junior and mid-level scientific staff

• Basic understanding of IP, contracting terms and provisions

• Effective communication is essential and includes presentations to effectively convey scientific concepts and data among research scientists, management teams within internal working groups/project teams, external academic and industrial organizations, review committees, and conferences. Writing for clinical protocols, reports, regulatory filings, and scientific publications is also required.


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.