Senior Scientist (Clinical Study Operations) - Tissue Diagnostics Assay & Drug Development

Competitive salary
Sep 06, 2016
Sep 28, 2016
Result Type
Position Type
Full Time

Senior Scientist (Clinical Study Operations) - Tissue Diagnostics Assay & Drug Development
Salary: Competitive
Location: Cambridge, UK
Reference Number: RD1739

Can you combine technical experience of tissue diagnostic assays with experience in clinical trial set-up and monitoring, and knowledge of the drug discovery and development process? This is an exciting time to join AstraZeneca’s Personalised Healthcare and Biomarkers (PHB) function in Cambridge as a Senior Scientist (Clinical Study Operations) - Tissue Diagnostics Assay & Drug Development, where you’ll help us challenge current scientific thinking and transform patients’ lives worldwide through personalising treatment.

We are investing in a new, state-of-the-art Global R&D Centre and Corporate Headquarters in Cambridge. This will reinforce our position as a world-leading pharmaceutical company and enable us to shape a brand new vision for our industry. You could be part of this vision, enjoying the facilities to innovate and pursue scientific excellence in your field, and growing your career in a culture that fosters multi-functional working and close collaboration with academia.

Main Duties and Responsibilities:

PHB within AstraZeneca focuses on matching medicines to those patients who will benefit from them most and delivers tissue-based diagnostic assays that align with the drug development process and enhance personalised healthcare approaches in our drug portfolio. As Senior Scientist (Clinical Study Operations) - Tissue Diagnostics Assay & Drug Development you will be responsible for the set-up and monitoring of new ImmunoHistoChemistry (IHC) and Fluorescence In Situ Hybridization (FISH) tissue diagnostic assays for clinical trial patient selection, working closely with internal and external partners in a global, multi-disciplinary environment.

Key Responsibilities:

  • Transferring diagnostic assay in laboratory testing networks to enable delivery in a clinical study setting
  • Preparation and review of documentation
  • Data monitoring and data quality control for ongoing clinical studies
  • Technical troubleshooting as required
  • Preparation of study reports and their presentation at study team meetings.

Essential Qualifications, Skills and Experience:

  • BSc or equivalent in molecular pathology, biomedical science, pharmacology or a related discipline
  • Excellent organisational skills, with the ability to deliver high quality work on time in full
  • Experience of drug discovery and development
  • Experience of clinical trial set up and monitoring
  • Understanding of analytical and clinical validation activities for In Vitro Diagnostic (IVD) devices / assays
  • Experience with tissue based biomarker assays, such as ImmunoHistoChemistry (IHC) and Fluorescence In Situ Hybridization (ISH), including troubleshooting and QC
  • Ability to communicate with stakeholders for study updates, testing progress through oral presentations and progress reports
  • Ability to collaborate with and influence internal and external partners.

Desirable Qualifications, Skills and Experience:

  • Knowledge of CRO, testing laboratories software packages (LIMS based, Web based systems used for sample tracking & data reporting)
  • An understanding of drug and companion diagnostic assay co-development and commercialisation.

We would also like to hear from those with strong technical experience and strategic understanding of tissue diagnostics.

To apply. please click on the 'Apply' button.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Applications Open: 6th September 2016
Applications Close: 28th September 2016