Senior Associate Scientist, Immunology

6 days left

San Diego, CA US
Competitive Salary
Sep 08, 2016
Oct 06, 2016
Clinical, Research
Result Type
Position Type
Full Time


Job title: Senior Associate Scientist, Protein Homeostasis

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


The Protein Homeostasis Thematic Center of Excellence (PH TCOE) is seeking a highly motivated Senior Associate Scientist with experience in immunology and immuno-oncology-based assays to participate in drug discovery research with a particular focus on protein homeostasis as it applies to the Immuno-Oncology field.  Emphasis will be in primary human immune cell biology assay development with a focus on T cell biology.  The successful candidate will work collaboratively in a multi-disciplinary environment to design and execute in vitro studies to further our understanding of the immunomodulatory effects of our novel compounds. Responsibilities will also include development of primary cell and cell-line based co-culture assays to support target validation, mechanism of action, and biomarker selection.  Experience with developing high-throughput screening assays a plus.  The responsibilities further include routine profiling of novel compounds in cell-based assays across several research programs. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCOE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities (will include, but are not limited to):

- Plan and execute scientific experiments
- Analyze and interpret scientific data

- Isolation of human primary cell populations
- Maintain primary and cancer cell lines and conduct routine cell culture tasks
- Conduct various routine cell based assays to characterize drug compounds
- Accurately maintain written reports and organize data
- Present data in team meetings
- Review current literature pertaining to relevant projects

Tasks and Responsibilities:

• Execute experiments independently.

• Interpret and discuss data.

• Trouble shoot.

• Familiar with literature.

• Role models for other scientists.

• Communicate via meetings and reports.

• Responsible for the completion of assignments that have an impact on functional goals.

• Able to coordinate CRO services.



• Works independently.

•Viewed as an experienced resource within their department.

• Provides input into experimental designs.


Creativity and Problem Solving:

• Improves efficiency and productivity within group or project.

• Understands departmental goals and development processes.

• Able to more fully interpret results and situations independently and articulate recommendations for resolution with strong scientific arguments.

• Recognizes risks and develops contingency plans.


Teamwork and Influence:

• Communicates with peers and supervisors.

• Begin to contribute to the achievement of workgroup/team goals.

• Key contributor to collaborative efforts.


Organizational Impact:

• Has a direct impact on department sub team or project team performance.

• Impact is achieved by helping lead workgroup(s).


Behavioral Competencies:

• Acts with integrity • Analysis of issues

• Building relationships • Coaching and developing others

• Delivers presentations • Develops systems & process

• Fosters open communication • Influence others

• Innovates • Manages execution

• Planning • Use sound judgment




Bachelor’s degree in a scientific discipline with at least 8 years work experience or Master’s degree with at least 6 years work experience.

Skills/Knowledge Required :

1.     Bachelor’s degree in a scientific discipline with at least 8 years industry experience or Master’s degree with at least 6 years industry experience.

2.     Practical experience in, and a solid understanding of basic cell biology, immunology/immune-oncology, and assay development.

3.     Extensive experience with mammalian cell culture (primary cells and cell lines) using single cells and co-culture cell models. Experience using single compound treatment and combination treatment studies is essential. Prior experience with small molecules as well as biologics is preferred.

4.     Expertise with a variety of cell-based assay technologies including antibody-based detection methods (e.g. Western, ELISA, MSD, Luminex, immunoprecipitation), cell imaging (immunofluorescence, Incucyte, Cellomics),  functional assays such as cell cycle and apoptosis and multiparameter flow cytometry is required.

5.     Experience with molecular biology techniques such as RNAi and/or CRISPR, RT-PCR, and lenti-viral work is a plus.

6.     Experience with the use automation instruments is a plus.

7.     Excellent communication, presentation, collaboration and organizational skills are required as well as the ability to independently design, execute, and trouble-shoot experiments through completion.

8.     Data analysis skills and experience with a variety of scientific software applications are required.

9.     The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to meet diverse project needs, and enjoy working in a fast-paced dynamic team environment.

Functional/Scientific/Technical Skills:

• Expert knowledge & demonstration of technical field.

• Generally independent in carrying out laboratory operations.

• Solid understanding of  Immunology and relevant scientific principals.

• Viewed as technically experienced and valued resource within department.

• Able to identify scientific and technical problems and potential solutions.

  Well organized in maintaining data and experimental records

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.