Scientist I, Research Analytics

Employer
Location
Massachusetts, US
Salary
Competitive Salary
Posted
Sep 21, 2016
Closes
Oct 19, 2016
Ref
16001706
Discipline
Clinical, Research
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


Position Summary:

We seek a talented, collaborative inter-disciplinary scientist to catalyze work on the computational analysis of high-dimensional tissue, cell and molecular profiling data. This individual will play a key scientific role leveraging innovative computational analysis strategies and rich patient data to empower data-driven decisions for therapeutic programs in Celgene’s Immune & Inflammatory (I&I) Thematic Center of Excellence (TCoE). The role will align directly with the Celgene mission to improve therapeutic outcomes in complex diseases of unmet medical need.

Applications range from providing deep insight into therapeutic mechanisms of action for both existing and novel therapies, to the identification of novel targets through functional genomics. There is a strong emphasis in integrated data analyses and interpretations from genetic, transcriptomic, proteomic, and imaging profiling platforms. Successful candidate will work in close collaboration with computational, biological and clinical scientists across the Celgene Research and Early Development organization.


Responsibilities will include, but are not limited to, the following:

•Perform computational analyses of high-dimensional datasets from model systems, experimental medicine and clinical trials to derive novel targets, biomarkers, mechanisms of action, and compound-phenotype insights.

•Leverage public datasets to facilitate the interpretations of internal data in empowering data-driven decisions across therapeutic programs.

•Data integration across assay platforms and knowledge transfer from pre-clinical experiments to clinical trials.

•Participation in scientific report writing. Presentation of methods, results and conclusions to a publishable standard.

•Contribution to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.



Qualifications
Ph.D and postdoctoral experience

Skills/Knowledge Required: •Ph.D. in genetics, computational biology, mathematics, statistics or related field from a recognized higher-education establishment. •Prefer 2 years post-doctoral experience applying quantitative approaches to solving biological problems in university, hospital, pharma or biotech environments. •Demonstrated ability to derive target mechanism of action from molecular signatures generated under perturbation. •Hands-on analyses of proteomics and imaging data strongly desirable. •Experience in functional genomics desirable.  •Expertise in algorithmic implementation, statistical programming and data manipulation, using e.g. R/Bioconductor, Matlab, Python, and contemporary, open-source bioinformatics tools and database structures. •Proven problem-solving skills, collaborative nature and adaptability across disciplines. •Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.


Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.