Senior Bioinformatician COMSIG

Cambridge, England
GBP31033 - GBP39142 per annum + excellent benefits
Sep 22, 2016
Oct 20, 2016
The Institute
Result Type
Position Type
Full Time

Salary range: £31,033 to £39,142 pa depending on experience.

An exciting Software Development opportunity has become available working with Dr Serena Nik-Zainal on several projects, including the clinical study INSIGNIA, which forms part of the research initiative COMSIG.

The COMSIG consortium, funded by a Wellcome Trust Strategic Award, is focused on exploring the mutational signatures of DNA damage and repair processes. This includes work performed across a range of model organisms (yeast, worm), as well human studies such as INSIGNIA, which are a key focus for Dr Nik-Zainal's team. As part of this we are generating human iPSC lines from patients with germline mutations in DNA repair/replication pathways and generating parallel CRISPr/CAS-9 edited iPSC lines of the same genes. The over-arching objective is to explore mutational signatures in the context of the biological mechanisms associated with DNA repair, by integrating cellular/molecular approaches with genome-wide assays including genomic sequencing, RNA-seq and ChIP-seq.

The successful candidate will be embedded in a multidisciplinary team and will be tasked with further contributing towards developing the analysis pipelines for this project and towards developing the public-facing website/database for the mutational signatures projects. The role involves working at the interface between scientific and IT staff on these projects to ensure efficient analysis of the DNA sequencing data sets. This website/database in envisaged as a reference resource for mutational signatures in the future.

The position would suit a Bioinformatician/Software Developer who enjoys developing or enhancing software tools for analysis of complex NGS biological data sets and to make these efficient, visually appealing and interpretable by the scientific/clinical community. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of mutational processes in human cells.

Essential Skills

  • Good degree in Bioinformatics or Computer Science with a scientific background.
  • Software development skills (using Perl and/or Python)
  • ORACLE/MySQL databases
  • Experience of handling Next Generation sequencing data
  • LSF or Open Grid scheduling software
  • Experience working, developing and compiling software tools in a UNIX/LINUX environment.
  • Enjoy working as part of a team

Ideal Skills

  • Software development using a compiled language (C,C++,Java)
  • Experience of statistical analysis in a bioinformatics (in R)
  • Experience of workflow management IT systems
  • Experience of VMware, OpenStack or Amazon Web Services (AWS)
  • Experience of working in an Agile Software Development Group
  • Web development using Perl, Java, HTML(5), CSS, JavaScript
  • Background in cancer genetics

Other information

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 19th October 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.