Postdoctoral Fellow - Bioinfomatician, Experimental Cancer Gene

Cambridge, England
GBP30655 - GBP38428 per annum + excellent benefits
Sep 23, 2016
Oct 21, 2016
The Institute
Result Type
Position Type
Full Time

Salary £30655 to £38428 per annum depending on experience.

Fixed Term Contract - 3 Years

The Experimental Cancer Genetics group at the Wellcome Trust Sanger Institute are seeking an outstanding Postdoctoral Fellow -Bioinformatician to contribute to the characterisation of mutational signatures and mutational landscapes from the genomes and epigenomes of lung tumours induced by carcinogen exposure.

We will leverage a significant resource of DNA of lung tumours from carcinogen-exposed mice and sequence the genomes of hundreds of mouse lung tumours. Our aim is to explore how exposure to carcinogens alters the genome by characterising mutational signatures, driver genes and tumour evolution. Unlike studies performed using cell lines we will assess the effect of mutagens and carcinogens on different tissues, in the context of an intact immune system, and also assess the role of other factors such as age or sex on tumour formation. Collectively, this work will be an extension of our papers recently published in Nature (Westcott et al., 2015) and Nature Medicine (McCreery et al., 2015) and is funded by Cancer Research-UK.

The Wellcome Trust Sanger Institute is a world leader in delivering large scale genome sequencing projects using the latest sequencing technologies and analysis methods. The Experimental Cancer Genetics group ( builds on the formidable bioinformatic resources of the the Cancer Genome Project ( to conduct hypothesis-driven research into the mechanisms of cancer development.

This role would suit a Postdoctoral Fellow with previous bioinformatics experience - especially in the analysis of somatic variation. The successful candidate will work closely with an established team of analysts and developers so previous experience with next-generation sequencing data is not strictly necessary.

Essential Skills

  • Demonstrable record in bioinformatics
  • Advanced degree (PhD) or equivalent research experience
  • Demonstrable record of computational data analysis
  • Excellent communication skills (written and verbal)
  • Proficiency in one or more scripting languages

Ideal Skills

  • Familiarity with the R programming language
  • Familiar with working on the unix command line
  • NGS data analysis
  • Experience in comparative genomics
  • Knowledge of mouse genetics or genomics

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 23rd October 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.