Advanced Research Assistant: High-through Gene Editing (Cell Cu
£24226 to £30537 pa plus excellent benefits
An Advanced Research Assistant position has become available in the High-throughput Gene Editing Core facility of the Wellcome Trust Sanger Institute. The facilities essential purpose is the provision of centralised instrumentation and expertise for customised genome editing of human induced pluripotent stem (iPS) cells using CRISPR/Cas9 technology.
We are currently looking for an enthusiastic and technically skilled individual to join the pipeline. Once trained, the postholder will be responsible for developing, conducting & troubleshooting routine and non-routine high-throughput tissue culture protocols.
The candidate will also hold other responsibilities that will aid in the development and running of the department. An Advanced Research Assistant would also be expected to quickly progress to a level where they are able to support and train more junior members of the team and take on added responsibility for discrete sections of the pipeline.
- Science degree in biological sciences or extensive, proven practical experience
- Strong working laboratory experience
- Practical experience of mammalian cell culture
- Experience in training others
- Experience in writing SOPs
- Good communication and willingness to present at team meetings
- Theoretical understanding of genome engineering techniques including CRISPR/Cas9
- Understanding of genotyping techniques (e.g. qPCR, HRMA)
- Ability to test and implement new approaches and techniques including troubleshooting
- Capable of working to a schedule and delivery of a variety of challenging projects simultaneously within agreed deadlines
- Ability to work both as part of a team and also independently once appropriate training and guidance have been provided
- Good computer skills in the use of office software (e.g. Excel, Word, Powerpoint)
- Experience of human ES or iPS cell culture
- An excellent understanding and practical experience in molecular biology strategies and techniques, including molecular cloning, nucleic acid isolation and purification, and PCR
- Practical experience of genome engineering techniques including CRISPR/Cas9Practical experience of genotyping techniques (e.g. qPCR, HRMA)
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focused around genomics, its applications, and implications. Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.
Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
Please include a covering letter and CV with your application.
Closing date: 19th October 2016