Post-Doctoral Scientist - Biotherapeutics

4 days left

South Mimms, Potters Bar
Up to £51517 per annum + benefits
Sep 28, 2016
Oct 26, 2016
Life Sciences, Virology
Result Type
Position Type
Full Time

POSITION:  Post Doctoral Scientist
DIVISION:  Biotherapeutics
LOCATION: NIBSC, South Mimms, Potters Bar, Hertfordshire EN6 3QG
REF NO: 1506569
GRADE AND SALARY: Grade 7 (£51,515)
TYPE OF CONTRACT:  Full time – Fixed Term (3 years)

The Medicines and Healthcare products Regulatory Agency enhance and improve the health of millions of people every day through the effective regulation of medicines and medical devices, underpinned by science and research. The agency is made up of circa 1300 staff working across two main centres and peripatetically across the UK and abroad.

A centre of the Medicines and Healthcare products Regulatory Agency, The National Institute for Biological Standards and Control (NIBSC) is a global leader in the characterisation, standardisation and control of biological medicines. NIBSC plays a major role in assuring the quality of biological medicines worldwide through the provision of biological reference materials, by testing products and carrying out research. Our expert scientists also provide advice on a routine basis and in response to emergencies. 

Purpose of the role:

The successful applicant will join the Haemophilia Laboratory within the Haemostasis Section of the Biotherapeutics Group at NIBSC, which is actively involved in R&D projects relating to immunogenicity of coagulation factor Factor VIII (FVIII), where the subsequent development of neutralizing anti-FVIII antibodies ("inhibitors") is a most serious adverse outcome in sufferers with congenital or acquired Haemophilia A, following substitutive FVIII therapy. Specifically this role offers an exciting opportunity for a Post-Doctoral Scientist to develop and lead research on the immunology of FVIII, leading to the recombinant development, expression and standardization of human FVIII antibodies in the evaluation of new approaches to quantification of FVIII inhibitors.

This includes the initiation and management of research projects; collaboration with academic and clinical partners; seeking external funding to supplement existing resources; and the presentation of research data at conferences and in scientific publications. The role will also supervise staff involved in the characterisation of recombinant antibodies and standardization of assays that assess FVIII immunogenicity.

Key responsibilities:

  • Initiate, develop and direct a program of research on the immunology of FVIII and its role in the development of FVIIII neutralizing antibodies in Haemophilia A patients, in order to enhance our understanding of safety and efficacy of various plasma derived and recombinant Factor VIII products.
  • Initiate and manage the recombinant production of a panel of human antibody reference materials/reagents relevant to quantification of FVIII inhibitors, including derivatives such as class and sub-class variants, from both known coding sequences for human anti-FVIII as well as from patient’s sera.
  • Manage and direct the scientific activities of the collaboration between NIBSC/MHRA and the Royal Free hospital.  Working with senior scientific and clinical staff in both organizations, interpret the overall goals of the collaboration, and, working with scientific autonomy and freedom to act, translate them into a deliverable program of scientific work.
  • Assist in the development of WHO International Standards for FVIII Inhibitors in the standardisation of inhibitor assays.
  • Collaborate with relevant external academic and clinical laboratories and other partners where appropriate.


  • A PhD in immunology or equivalent qualification or experience in relevant field


  • Proven post-doctoral research experience in Factor VIII Immunology (or equivalent), with good experience in expression & protein purification of recombinant proteins.
  • Previous experience supervising graduate and undergraduate research projects.
  • Some experience in coagulation and haemostasis assays.


How to apply:

You can apply for this position by creating a job profile on the Civil Service Jobs Portal by clicking on the 'Apply' button

Our process requires that you apply for roles through Civil Service Jobs, where you will be asked to complete an application form and answer some competency based questions. Depending on the level of the role you are applying for this generally takes between 25 – 40 minutes so please allow sufficient time.

We are an equal opportunities employer and welcome applications from suitably qualified people regardless of age, gender, sexual orientation, marital status, race, religion, politics or disability.

The closing date for applications is 9th October 2016