Senior Scientist, Enzymology

1 day left

San Diego, CA US
Competitive Salary
Sep 28, 2016
Oct 26, 2016
Clinical, Research
Result Type
Position Type
Full Time


Job title: Senior Scientist, Structural and Chemical Biology

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.



Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide.  We are a global biopharmaceutical company with operations in more than 60 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology and inflammation. If you’d like to join a company where you can make a difference, please consider the Celgene family.


We are seeking a highly motivated and experienced industry scientist to join our Epigenetic Center of Excellence. The successful candidate will have a well-documented background of scientific expertise in epigenetics with a high interest in drug discovery. He/she will work on drug discovery projects focused on epigenetic targets. Specifically, the candidate will be expected to design, plan and execute biochemical studies that include assay development, screening and mechanism of action studies for identifying and profiling development compounds within the area of epigenetics.

The candidate must be highly motivated, innovative and a strong team player. Excellent time management and organizational skills, strong written and oral communication skills and the ability to work in a fast-paced environment are essential. The qualified candidate must possess strong interpersonal and communication skills with a demonstrated ability for creative thinking and problem solving.




Ph.D. in Biochemistry with at least 6 years of relevant work experience, biotech or pharmaceutical experience, preferred.


This position requires a PhD in biochemistry, solid enzymology skills, at least 6 years of productive research experience in epigenetics at the postdoctoral level, as evidenced by an excellent publication record. Previous experience in the biopharmaceutical industry with successful record on project impact and compound progression will be  a plus.


Relevant technical skills:

-        Strong epigenetic background and understanding of transcriptional regulation

-        Advanced understanding of enzymology and reaction kinetics

-        Characterization of enzyme inhibitors and mechanism-of-action studies

-        Experience in developing robust enzyme assays and miniaturization for high throughput screening

-        Experience with FRET, SPR, and mass spectroscopy is highly desirable

-        Analysis of both biochemical and cellular structure-activity relationships

-        General awareness of drug discovery and development process

-        Ability to write invention disclosures, technical reports, protocols and scientific publications

-        Ability to engage with industry and academic collaborators

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.