Principal Scientist, Cellular Therapeutics

3 days left

Warren, NJ US
Competitive Salary
Sep 29, 2016
Oct 27, 2016
Clinical, Research
Result Type
Position Type
Full Time


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.


The Principal Scientist position is responsible for providing scientific and technical leadership to enable the development of innovative and life-changing cellular immunotherapies within the R&D Immuno-Oncology Discovery Project at Celgene Cellular Therapeutics. The Immuno-Oncology Discovery Project is focused on creating novel cell therapy products from genetically engineered immune cells to fight cancer. By employing state of the art gene editing techniques (such as CRISPR-mediated genome editing, viral vectors based genetic modification) and various mammalian expression systems, the candidate will define novel cell types for therapeutic candidate development. The successful individual will demonstrate subject matter expertise, deep scientific knowledge/execution drive, and the ability to critically evaluate scientific data required to move projects forward. The position will require an individual with strong analytical, leadership and communication skills (both written and oral) and the ability to work with a variety of individual styles. Deep scientific expertise in Immune Cell Biology (such as NK cells, T cells) and direct experience with Cellular & Molecular Immunology and Molecular Biology is required.


Responsibilities will include, but are not limited to, the following:

·          Provides leadership capability to project/project team, creates and tracks achievable goals for the team that are aligned with Corporate and Divisional Objectives, designs and carries out laboratory experiments for discovery, research and early development of immune-oncology projects

·          Develops scientific strategies, and accountable for project success and deliverables

·          Has direct impact on the performance of multiple departments through leading project teams and contributing to cross-functional teams

·          Provides in-depth analysis & interpretations of diverse experimental results

·          Serves as subject matter expert and functional group advisor on science, technology and methods

·          Independently designs and implements long-term project plans and appropriate experiments that define efficacy and mechanism of action of the cellular product via gene, protein and function-based in vitro assessments

·          Improves current functional assessment approaches by designing pertinent novel cell-based assays and/or cellular immune-based assays

·          Provide recommendations for, and implement studies and strategies to define the phenotypic and functional characteristics of the cellular product in pertinent in vivo studies

·          Supervise contract research organizations to achieve high standards of productivity and quality

·          Present work at project team/franchise team meetings, internal forums, and external meetings

·          Provide scientific progress reports to the Senior Director and/or Senior Management as required

·          Author and oversee writing of study reports, patents, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards

·          Prepare IND format documentation and / or reports based on scientific results as required

·          Manage projects to successful outcomes through scientific leadership, teamwork and influence, and potentially direct reporting relationships

·          Develops research staff through instruction, coaching and guidance


PhD or MD/PhD (Postdoc/Fellowship required)

Skills/Knowledge Required / Desired :

· PhD or MD/PhD in a relevant field, Immune Cell Biology (such as NK cells, or T cells), Cellular & Molecular Immunology and Molecular Biology, with post-doctoral/fellowship experience plus at least 5 years of relevant work experience are required

· Advanced multi-parameter flow cytometry skills are required

· Demonstrated expertise of a wide range of in vitro cellular and biochemical assays, including cell isolation and culture, molecular biology, cellular immunology assays and familiarity with in vivo models of immune disease or oncology are required

· Track record of success as evidenced by a strong publication record, and/or, evidence of sustained contributions in the biopharmaceutical industry

· Proven track record of scientific approach to complex problem solving, able to anticipate problems at project level and interpret contingency plans, identifies solutions and strategies, and implements appropriate  scientific actions

· Proven ability to derive novel insights from complex data

· Comprehensive knowledge of cancer biology, target selection, target screening, immunotherapy, state of the art genetic engineering techniques in both cell lines and primary cell cultures, and mammalian expression vectors

· Ability to interpret and summarize scientific data in an accurate, critical and concise manner

· The individual is also expected to establish and manage productive collaborations with academic researchers and contribute to the scientific community by publishing results in high quality journals

· Must work effectively in a matrix environment, qualities of scientific leadership are particularly sought

· Must be a team player, able to collaborate across multidisciplinary terms, and also have the ability to work independently

· Proven ability to produce invention disclosure and patent applications

· Effective communication is essential and includes presentations to effectively convey scientific concepts and data among research scientists, management teams within internal working groups/project teams, external academic and industrial organizations , review committees, and conferences. Writing for clinical protocols, reports, regulatory filings, and scientific publications is also required

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.