Associate Scientist, Biotherapeutics

5 days left

San Diego, CA US
Competitive Salary
Sep 30, 2016
Oct 28, 2016
Clinical, Research
Result Type
Position Type
Full Time


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


Summary/Scope   Celgene Biotherapeutics is seeking a highly motivated and experienced Associate Scientist. The successful candidate needs to have a strong background in molecular and cellular immune biology with experience in oncology or immunology drug discovery. The qualified candidate will participate in testing novel antibody candidates in functional assays in addition to performing mechanism-based in vitro studies. This candidate will adapt and implement existing or novel HTS platforms to assess target binders for functionally in relevant systems to support multiple programs at varying stages of antibody discovery. Excellent communication and interpersonal skills demonstrated in a team environment are essential, as well as experience with software applications for storing, processing and presenting data.   Responsibilities will include, but are not limited to, the following:
  • Coordinate the testing of incoming biologics for cellular target binding and related functional activity.
  • Based on directions from supervisor, design and execute complex human cell based assays and mechanism of action studies. Also, perform routine and complex data analysis to triage leads for affinity maturation.
  • Isolate and expand human  primary immune cell populations for in vitro functional assays.
  • Perform routine Biotherapeutics assays on identified antibody leads prior to DC nomination, including FcgR binding, effector function, and human cytokine release.
  • Cross-trained in multiple flow cytometry platforms and high content imaging systems. Also have the capacity to assist colleagues in performing flow and imaging analysis.
  • Routine presentations of experimental plans and data in team and department settings.

  • Qualifications



    Bachelor’s degree in a scientific discipline with at least 6 years work experience or Master’s degree with at least 4 years work experience.


    Skills/Knowledge Required: 
    • Familiar with multi-parameter flow cytometry analysis (surface/intracellular staining) using LifeTechnology Attune, BD Canto FACsCalibur. Experience in Mirrorball cytometers or Operetta High Content Imaging system a plus.
    • Proficiency with FlowJo, Prism, Microsoft office applications
    • Expert understanding in tissue culture, human and cynomolgus immune cell isolations, and familiarity with gene reporter systems.
    • Solid understanding of macrophage related biology and cellular immunology.
    • Familiarity in molecular and biochemistry techniques, including cell transfections, Western blotting, DNA manipulations, and qPCR analysis, are a plus.
    • Fundamental knowledge and understanding of drug discovery and antibody discovery process is preferred.


    Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.


    Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.