Scientist II, Investigative Toxicology

4 days left

Summit, NJ US
Competitive Salary
Oct 01, 2016
Oct 29, 2016
Chemistry, Toxicology
Result Type
Position Type
Full Time


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.


The Scientist II in Investigative Toxicology serves as an integral member of the team that supports investigative toxicology studies, in both in vitro and in vivo. This scientist will be responsible for technical activities related to molecular/cellular toxicology with emphasis on microphysiological model and emerging technologies development/validation, identifying mechanisms of toxicity, and reporting results to NCD and Project teams as appropriate. The Scientist II is also responsible for contributing to the long-term strategic goals and tactical objectives of the Investigative Toxicology group.

Responsibilities will include, but are not limited to, the following:

•Design and conduct in vitro and molecular toxicology experiments focused on identification of mechanistic basis of toxicity including the following capacities.

oCharacterization of biomarker, protein and/or mRNA on investigative studies using -omic technologies.

oTissue culture systems such as conventional cell culture, co-culture models, organ culture systems, and utilization of stem cells and stem cell derived tissues

oEvaluation of data using appropriate software, and  interpretation/integration of results from multiple molecular endpoints to generate reports with a focus on toxicological relevance

oWork collaboratively to integrate data from molecular endpoints with traditional toxicity endpoints

oManage and conduct in-house and outsourced in vivo and in vitro toxicology studies

•Contribute to identification of safety risk based on understanding of pharmaceutical action, literature knowledge on pathways and/or toxicological profile of competitor drugs to enable more effective investigative toxicology studies.

•Facilitate collaboration with academic centers and toxicology consultants as necessary to complete investigative studies.

•Maintain molecular toxicology expertise through organizational associations, literature review, continuing education, and publications.

•Establish and maintain working relationship with key opinion leaders in the toxicology community, academicians, and key Celgene staff

•Support Investigative Toxicology by 

o Addressing development issues and conducting risk mitigation activities

o Evaluating and implementing novel toxicology models and assays (e.g.,               BM and gut)

o Supervise and mentor scientific staff

o Publishing findings

o Address scientific issues using knowledge of molecular toxicology

o Working closely with Celgene Exploratory Toxicology colleagues at                     Discovery sites

• Address scientific issues using knowledge of molecular toxicology


Ph.D. with at least 4 years of work experience in toxicology or related mechanistic biology field, preferable in Pharma.  Master’s degree with at least 10 years work experience or Bachelor’s degree with at least 12 years work experience.  Requires a working knowledge of drug discovery and development process and demonstrated laboratory skills suitable for investigative toxicology.
Skills/Knowledge Required: •Advanced knowledge of general, cellular, and molecular toxicology principles.   •Experience conducting mechanistic investigative studies involving signal transduction pathways, proteomics, and genomics •Familiarity with in vitro toxicology models, assay design, validation, rationale, and mechanistic principles desired. •Familiarity with in vivo toxicology study design and conduct •Understanding of emerging technologies including microphysiological systems a plus

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.