Scientist II, Translational Medicine

Cambridge, MA US
Competitive Salary
Oct 05, 2016
Nov 02, 2016
Clinical, Research
Result Type
Position Type
Full Time



Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.





The Translational Development group is seeking a self-motivated, enthusiastic candidate with strong background in cellular immunology and molecular biology. The primary focus of this position will be to evaluate the functional significance of specific human polymorphisms (SNPs) associated with Immunology/Inflammatory-related diseases.  The work will support therapeutic target validation efforts as well as patient segmentation strategy for specific disease areas and targets.  The candidate will coordinate the generation of gene edited cell lines and recombinant cell lines and will then characterize them using various cellular assays to determine the functional consequence of relevant genetic alterations. The candidate will participate in a broad range of programs in a dynamic, small research group and be comfortable working in a fast paced environment. Strong problem solving and time management skills are essential to complete diverse assigned tasks. Industry experience is preferred but not essential.


Responsibilities will include, but are not limited to, the following:

1.     Coordinate the generation of gene edited cell lines and recombinant DNA through external commercial partners

2.     Generate recombinant cell lines expressing wild-type and mutated forms of specific genes

3.     Design, plan and execute cell based assays with gene edited and recombinant cell lines and/or human primary cells/tissues

4.     Utilize primary patient samples to generate genetic, transcriptomic, proteomic, functional, and clinical datasets with targeted therapeutics for signal seeking and hypothesis testing.

5.     Maintain well written and accurate research electronic notebook detailing work undertaken

6.     Comply with laboratory safety procedures








Phd with at least 6 years work experience preferred.


Bachelor’s degree in life sciences with at least 12 years work experience or Master’s degree with at least 10 years work experience.




Skills/Knowledge Required :

1.     Extensive experience in isolation, culture, and characterization of cell lines and primary cells from human

2.     Strong hands-on experience with common immunological assays (cell activation, proliferation assays, cytokine analysis by FACS and ELISA, and multiplex assays)

3.     Experience with immune cell activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting.

4.     Experience in the field of immunology and inflammation is required.  Experience on inflammatory bowel diseases or pulmonary fibrosis is preferable.

5.     Proficiency with FlowJo, Prism, and Microsoft office applications

6.     Possess a thorough knowledge of experimental design and underlying scientific principles

7.     Excellent organizational, record keeping, oral and written communication skills

8.     Team player and organized





Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.


Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.