Principal Safety Scientist - DNA Damage Response (DDR)

Location
Cambridge, England
Salary
Negotiable
Posted
Oct 07, 2016
Closes
Oct 28, 2016
Ref
R-000224
Result Type
Jobs
Position Type
Permanent
Hours
Full Time

As the Discovery Safety Principal Scientist - DDR you'll provide leadership in DDR safety science, through the innovative application of cellular / molecular biology and a strong understanding of DDR biological mechanisms. Specifically, you will provide scientific leadership of the development of complex biological models that will enable the dissection of DDR biology in health and disease.

At AstraZeneca in Cambridge, we have an exciting opportunity for an experienced DNA Damage Response (DDR) Biologist to join our Discovery Safety team as a Principal Scientist.

Our established DDR portfolio includes Olaparib/LynparzaTM, AZD1775, AZD6738, AZD2811 and AZD0156, and we are the only major pharmaceutical company in the UK with a clear commitment to oncology. Our new, state-of-the-art Global R&D Centre in Cambridge will become our focal point for oncology research and offer our talented scientists unrivalled facilities to continue to build our reputation as global experts in DDR.

Your deep understanding of DDR biology will help drive safety evaluation and provide scientific leadership in the application of cutting edge in-silico, molecular, cellular and in-vivo techniques to assist in the discovery of new and effective medicines. You will be encouraged to identify opportunities to deliver enabling safety strategies, built on strong biological understanding, across both our discovery and development portfolios for both monotherapy and combination approaches.

Main duties and responsibilities:

As a member of the UK Discovery Safety team within Drug Safety and Metabolism (DSM) you will be responsible for providing leadership in DDR safety science, through the innovative application of cellular / molecular biology and a strong understanding of DDR biological mechanisms. Specifically, you will provide scientific leadership of the development of complex biological models that will enable the dissection of DDR biology in health and disease. You'll develop and deliver novel experimental strategies and scientific developments that help understand DDR biology and advance our DDR portfolio.

In addition, you'll act as Discovery Safety Specialist on project teams, providing overall safety leadership and guidance through the discovery phase of projects. You will work in collaboration with highly skilled, motivated colleagues from across our organisation to apply in-silico, in-vitro and in-vivo approaches, to help solve complex problems.

Combined, these two core responsibilities with provide you with the opportunity to drive forward our scientific and biological understanding of DDR biology as it relates to drug safety, while simultaneously applying this to active drug discovery projects across the breadth of our DDR portfolio.

We're offering:

  • A world-class research environment
  • One of the most exciting R&D pipelines.
  • A collaborative working culture and the opportunity to engage with talented scientists from across drug metabolism & pharmacokinetics, chemistry, biology and clinical disciplines.
  • An environment where science is at the forefront of everything we do, where considered risk taking and creativity are rewarded, and opportunities for growth and development are created.

At AstraZeneca we aim to be a great place to work, and as part of this commitment support flexible working arrangements where possible, typically including one day per week working from home.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Applications Close: 1st November 2016

Essential requirements:

  • PhD or equivalent experience in DDR biology or relevant area of cancer biology.
  • Expertise in DNA damage induction and signalling responses at molecular and cell biology level.
  • Expertise in the design and execution of cutting-edge experiments to determine the effects of molecules on biological systems.
  • An established publication record in high quality journals
  • An innovative and creative mind-set
  • A collaborative approach to problem solving.
  • Strong communication skills and the ability to work effectively with a diverse range of colleagues.

Desirable requirement:

  • Experience of working within project teams within a drug discovery environment, and experience of in vitro and in vivo preclinical safety strategy development.
  • Experience of the drug discovery and development process, with an appreciation of disciplines both within and outside toxicology.