In-Vitro Scientist Bone Marrow Toxicity - DNA Damage Response

Cambridgeshire, England
Oct 07, 2016
Oct 28, 2016
Result Type
Position Type
Full Time

As In-Vitro Scientist in Bone Marrow Toxicity - DNA Damage Response (DDR) you'll be responsible for the design, conduct and interpretation of in-vitro experiments designed to evaluate and mitigate potential haematotoxicity.

At AstraZeneca in Cambridge, we have an exciting opportunity for an experienced In-Vitro Scientist in Bone Marrow Toxicity - DNA Damage Response (DDR) to join our Discovery Safety team on a Fixed Term Contract until the end of 2017.

Our established DDR portfolio includes Olaparib/LynparzaTM, AZD1775, AZD6738, AZD2811 and AZD0156, and we are the only major pharmaceutical company in the UK with a clear commitment to oncology. Our new, state-of-the-art Global R&D Centre in Cambridge will become our focal point for oncology research and offer our talented scientists unrivalled facilities to continue to build our reputation as global experts in DDR.

This is an opportunity to join our Discovery Safety team developing and applying in-vitro models of human bone-marrow, as we build our capability in DDR safety biology. We are increasing our investment in the development of both traditional 2D and advanced 3D microphysiological systems of bone marrow biology and toxicology, and seek a lab based scientist who can help us fully exploit this exciting technology. With a hands-on, 'lead-from-the-lab' approach, you'll help shape the experimental design, practical delivery and interpretation of in-vitro data. This is an opportunity for a highly motivated scientist to join our industry leading group supporting drug safety assessment - a critical component in our drug discovery and development process.

Main duties and responsibilities:

As a member of the UK Discovery Safety team within Drug Safety and Metabolism (DSM) you will be responsible for the design, conduct and interpretation of in-vitro experiments designed to evaluate and mitigate potential haematotoxicity. You will work closely with other safety scientists and discovery safety specialists to delivery optimized experimental approaches and project support across our DDR portfolio. You will use your scientific knowledge and expertise to recommend appropriate experimental strategies, interpret data and develop the ongoing experimental strategy. In addition you will:

  • Work in close collaboration with Discovery Safety Specialists, to set and answer critical project safety questions
  • Develop innovative solutions and research proposals that address capability gaps in predictive safety science
  • Ensure compliance with relevant regulations and standards

Essential requirements:

  • An MSc or equivalent (a BSc with relevant experience) in a relevant discipline.
  • Strong laboratory-based skills in molecular biology and/or in vitro cell-based models
  • Expertise in the design and execution of in-vitro experiments to determine the effects of molecules on biological systems.
  • Significant, direct experience in the design and execution of molecular biological, biochemical and/or cellular experiments to determine the effects of therapeutics on biological systems.
  • An awareness of new in vitro methodologies through literature and networking.
  • An innovative and creative mind-set.
  • A collaborative approach to problem solving.
  • Strong communication skills and the ability to work effectively with a diverse range of colleagues.

Desirable requirements:

  • Expertise in in-vitro approaches for assessment of bone marrow toxicity.
  • Experience of stem cell, 3D, or microphysiological systems.
  • Recognised experience in the in vitro field via peer-reviewed publications.
  • A good understanding of the Drug Discovery and Development process.

We're offering:

  • A world-class research environment, with the opportunity to apply innovative scientific thinking to one of the most exciting R&D pipelines.
  • A collaborative working culture and the opportunity to engage with talented scientists from across multiple disciplines
  • An environment where science is at the forefront of everything we do, where considered risk taking and creativity are rewarded, and where there are significant personal opportunities for growth and development.

At AstraZeneca we aim to be a great place to work, and as part of this commitment support flexible working arrangements where possible.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Location: Cambridge, UK

Salary: Competitive, plus Excellent Benefits Package

Applications Open: 4th October 2016

Applications Close: 1st November 2016