Research Fellow, T cell receptor mechanobiology

Boston, Massachusetts (US)
Salary Depends on Experience
Oct 07, 2016
Dec 02, 2016
Result Type
Position Type
Full Time

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

T cell receptor mechanobiology and protective immunity

A postdoctoral position is available immediately to participate in an exciting area involving the relationship of single TCR-pMHC bond lifetimes under load and protective CTL immunity. The successful candidate must have a PhD or equivalent with several years of relevant post-doctoral experience and be highly motivated. He/she will work with a team of immunologists, structural biologists and mass spectroscopists seeking to explore the details of how different T cells specific for the same pMHC manifest differential protection. He/she will define characteristics of those CTL with greatest activity for CD8 vaccine development against infectious pathogens as well as viral tumor antigens. The ideal candidate should have excellent skills using in vivo mouse models, single cell PCR repertoire analysis and molecular biology, T cell functional studies including retroviral transduction of T cells, cell growth and cytokine/effector assays as well as multi-color flow cytometry. Biochemical skills and experience with human cells are useful but not essential.

If interested, please send your CV, a brief summary of research experience and names of three referees to: Ellis Reinherz, MD, Professor of Medicine, Harvard Medical School and the Department of Medical Oncology, Dana-Farber Cancer Institute, 35 Binney St., JF518, Boston, MA 02115; Email:

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.




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