Antibody discovery Scientist (Scientist I/II)

Cambridgeshire, England
Oct 10, 2016
Nov 07, 2016
Result Type
Position Type
Full Time

Antibody discovery Scientist (Scientist I/II)

Salary: Competitive

At MedImmune, relentless pursuit is matched with exceptional capabilities to break new ground in science. We have one of the most robust pipelines in the industry, and it's because of our people. We're entrepreneurial and deeply collaborative - a winning combination that's delivering life-changing medicines to patients.

We're constantly pushing the boundaries of science to deliver life-changing medicines to patients,

with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

Making the impossible a reality can mean taking a chance on an idea and investing in our exceptional capacity for innovation and discovery. We champion trying new things, and we nurture a test and learn culture that means we are always progressing close to our goals.

Based in Cambridge, the Antibody Discovery and Protein Engineering team are looking to employ a scientist to generate therapeutic antibodies and tool reagents using hybridoma technology and phage display.

Some of the responsibilities include:

  • Independently plan, design and conduct experiments to:
    • Isolate monoclonal antibodies by hybridoma technology including: design of appropriate immunization strategies, B-cell fusions, hybridoma selections, sequence analysis of hybridoma clones, hybridoma propagation and antibody purification.
    • Isolate antibodies from na├»ve antibody libraries using in vitro display technologies.
    • Generate tailored libraries and select for optimized variants using in vitro display technologies or rational engineering.
    • Characterise lead antibodies in biochemical and cell based assays.
  • Provision of expert knowledge to multidisciplinary project teams to impact project-related decisions.
  • Definition and implementation of process improvements.
  • Assessment and implementation of technology improvements.
  • Effectively presenting results at internal meetings and external scientific meetings.
  • Contributing toMedImmune's external presence by publication in peer reviewed journals in the field.

    To be considered, successful applicants will need to be educated to PhD level or equivalent experience in a relevant discipline. You will also need to have experience in the following:

  • Proven practical scientific experience of isolating antibodies using hybridoma technology and/or phage display.
  • Knowledge of automation, informatics and data management
  • Ability to work inmulti-disciplinary teams

    Essential Requirements

  • Displays a general knowledge of drug development.
  • Experienced molecular biologist.
  • Excellent scientific communication skills enabling effective working with colleagues at all levels.
  • Ability to author and publications and raise external visibility of the team via conference presentations and other means.

    Desirable Requirements

  • Experience of biochemical and cell based screening.

    Closing Date: 30th November 2016

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.