Team Leader, Early Product Development

Cambridgeshire, England
Oct 10, 2016
Nov 07, 2016
Result Type
Position Type
Full Time

Team Leader, Early Product Development (Pharmaceutical Sciences)

Salary: Competitive

Location: Macclesfield, prior to relocating to Cambridge, UK

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.

Pharmaceutical Sciences is a newly created department within our Innovative Medicines and Early Development (IMED) Biotech unit. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes and manufacturing of Active Pharmaceutical Ingredients (API). Our portfolio of projects include traditional small molecules to nucleotide based therapies and nanomedicines across AstraZeneca's therapy areas.

This is an exciting opportunity to join the Pharmaceutical Sciences group in Cambridge. Reporting into the Head of Early Product Development, as a Team Leader you will be accountable a portfolio of early discovery oncology compounds from Lead Generation to Candidate Selection.

Through a focus on the patient experience, an intimate understanding of the disease state and the commercial setting, you and your team will influence the design of candidate drugs that have an enhanced potential to become successful products. You will draw on your extensive understanding of product development, manufacturing, chemistry, drug delivery and emerging technologies to bring forward innovative new opportunities.

You will be responsible for the personal development of your team members and will coach them in their project and scientific activities. You will collaborate on projects with colleagues within Pharmaceutical Sciences and other AstraZeneca functions in order to drive the implementation of strategic and scientific work. You will have the accountability to ensure that the team develops and delivers scientifically innovative, valid, risk assessed, prioritised programmes to deliver the project needs. The projects will span a range of complexity, routes of administration and type of active agent, and may include collaborations with external companies or organisations, or scientific research programmes.

The Team Leader will leverage the strong relationships they develop with colleagues across the IMED to ensure Pharmaceutical Sciences and the pharmaceutical sciences play a seamless, integrated role in the IMED projects, contribute timely and relevant scientific input, and be a champion for the group.

As Team Leader your impact will primarily be on people development, project delivery and scientific leadership. Your impact on the wider business is through the development of local, regional and global solutions which improve customer interfaces and product development across a portfolio of projects. You will have impact externally, proactively continuing to drive your own personal scientific leadership through e.g. publications, presentations, collaborations, seeking new technologies etc.

Some of the responsibilities include:

  • Leading, coaching, developing and managing a multi skilled team of approximately 8 scientists
  • Influencing and contributing to compound design, assessing the developability of new drug candidates and enabling pre-clinical studies.
  • Developing and delivering scientifically valid, risk assessed, prioritised programmes to deliver the project needs.
  • Managing and delivering a complex portfolio of early projects through the team and with collaboration across the global EPD group.
  • Identification and implementation of new science and technologies within the team and the wider EPD group
  • Establishing and maintaining excellent networks & collaborations with key iMed stakeholders.
  • Ensuring SHE and GXP compliance, and that all work is carried out to AstraZeneca and external regulatory policies and standards

Essential Requirements

  • Either undergraduate/ Masters level qualification with several years' experience within the pharmaceutical sector, or a PhD level qualification (preferred).
  • Experience of, or exposure to, multiple disciplines in Pharmaceutical Development (CMC) and related functions (e.g. Discovery, Operations and Clinical).
  • Thorough understanding of principles, applications and management of SHE and GXP.
  • Track record as a scientific leader, providing scientific challenge and direction to team members
  • Line of sight & preferably knowledge of the overall drug development process from Discovery through to Launch
  • Knowledge of multiple disciplines in pharmaceutical science (CMC) and related functions (e.g. Discovery, Operations and Clinical).
  • Broad multidisciplinary CMC experience with particular experience in influencing compound and product design

Skills and Capabilities:

  • Excellent communication, team working, networking and leadership skills & ability to lead and inspire team members
  • Ability to manage & deliver a complex portfolio of projects
  • Judgement of appropriate amount of resource and activity required for different drug projects and S&T work.
  • Ability to drive and lead science personally and within the team, the projects and manage external collaborations
  • Change management capability and continuous improvement mind-set and ability to lead strategic workstreams.
  • Ability to develop solutions to a diverse range of problems requiring complex judgements based on highly developed level of conceptual thought, strategic vision and analysis.

Applications Open: October 10th 2016

Applications Close: November 13th 2016

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.