Laboratory Technician / Technical Assistant or equivalent (m/f) for Synthetic Organic Chemistry

Dortmund, Nordrhein-Westfalen (DE)
Oct 13, 2016
Nov 10, 2016
Result Type
Position Type
Full Time

Job Description

Under the supervision of the Laboratory Head, you will be responsible for the synthesis, purification and characterization of novel organic molecules, as single compounds as well as in parallel, using state-of-the art methods, techniques and equipment. Milligram to multigram scale synthesis will be necessary, depending on project requirements. Maintenance of purification and analytical equipment as well as general lab support activities will also be part of your daily routine. Appropriate documentation of your results and compound registration in the proprietary database are also among your duties. The position is intended permanent and full-time with an initial trial period of six months.

We offer

The above position offers a lot of variety within the area of synthetic organic chemistry. With the support of a strong team, and depending on experience, you will be able to work independently and devise your own synthetic routes to deliver target compounds. In return for your above average motivation, chemistry knowledge and flexibility, we offer an attractive salary package and good personal development possibilities.

Who you are

The successful candidate (f/m) will have, ideally, 2 years hands-on experience in synthetic organic chemistry within an academic or industry setting.

Further requirements are:

Experience in the following areas of organic chemistry: milligram to multigram scale synthesis, working under inert conditions, standard purification techniques such as column chromatography and preparative HPLC, analytical techniques such as 1H-NMR and LC-MS.

Theoretical knowledge of standard organic chemistry reactions, for example substitutions, oxidations, reductions, reductive aminations, Suzuki couplings, amide formations…

Good working knowledge of the current chemical and MS-Office Software, for example Word, Excel, Chemdraw… Knowledge of scientific search engines such as Sci-Finder is an advantage.

Good English and communication skills.

Who we are

The Lead Discovery Center (LDC) was established in 2008 as a novel approach to capitalize on the potential of excellent research for the discovery of new therapies for diseases with high medical need. The LDC works closely with academic inventors to integrate their specific expertise and to draw on their unique tools, technologies, models, methods and materials. Collaborating with both academia and industry, the LDC functions as a facilitator to translate academic basic research results into professional drug discovery projects and high quality products that can be readily commercialized.

Our aim is to transform promising early-stage projects into innovative pharmaceutical leads that reach initial proof-of-concept in animals.

With a world-class team of interdisciplinary scientists, drug discovery experts, pharmacologists and seasoned project managers, the LDC offers the full scope of drug discovery support – from target to lead – according to the highest industry standards.

The LDC consists of four scientific departments: Medicinal Chemistry (MedChem), Assay Development & Screening, Pharmacology and Biology and offers the full workflow in early pharmaceutical drug discovery, covering all necessary technologies and equipment, ranging from drug design to sophisticated chemical synthesis and biological and pharmacological profiling. MedChem includes compound design as well as single compound and parallel organic synthesis in the MedChem Labs, and computational chemistry analyses performed by experts.

 A typical MedChem Lab consists of a Laboratory Head (PhD) with multi-year industrial experience, whose primary tasks range from molecule design, medicinal chemistry based interpretation of biological and pharmacological data (establishment of structure-activity and structure-property relationships -SAR, SPR-) to internal or external reporting. Each Laboratory Head supervises a small team of Laboratory Technicians, who are responsible for the synthesis, purification, analysis and documentation of the target compounds designed by the Laboratory Head, along with maintenance of the required equipment and smooth organization of the lab routines.